I just signed up with ASO; I transferred my domain from elsewhere. Now I want to register domain names for two blogs. Is there a major advantage to opening new accounts so that each has its own cpanel, or can I run all three from my first account.

Many thanks,
Scal

Might be easier to get a slightly larger plan and get reseller option which gives you WHM and the opportunity to give cpanel to "sub-accounts" as you with.